The alpha-Klotho and beta-Klotho took their name from the first of the three degrees of Greek mythology. Klotho represents the present in people's lives and is considered the largest and most important of the other two. It was believed that the thread of every man's life, his destiny, that accompanied him until his death, was spun with its rocket. They also made important decisions, such as when a person would be born, and therefore greatly influenced human lives. In fact, her power allowed her to choose who would die and who would be saved or brought back to life, as in the myth of Pelops.

These hormones are thought to play a role in the aging process, as they regulate metabolism and regulate human life expectancy. Two separate studies have unlocked the function of Cloth proteins and shed more light on diseases such as heart disease.

Researchers at the New York School of Medicine studied the relationship between alpha-Klotho hormone and fibroblastic growth factor 23 (FGF23). 20-year studies in rats concluded that artificial deficiency of FGF23 protein led to the appearance of aging. The study was published in the journal Nature.